Pracinostat

Product Name: Pracinostat
CAS No.: 929016-96-6
Chemical Name: Pracinostat
Synonyms: SB939;CS-60;Pracinostat;SB939, >98%;Pracinostat, >=98%;Pracinostat (SB939);SB 939 Pracinostat;SB939; SB-939; SB 939;Pracinostat USP/EP/BP;Pracinostat Hydrochloride
CBNumber: CB32537549
Molecular Formula: C20H30N4O2
Formula Weight: 358.48
MOL File: 929016-96-6.mol

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Pracinostat Property

Density: 1.11
storage temp.: Store at -20°C
solubility: insoluble in H2O; ≥11.4 mg/mL in DMSO; ≥24.8 mg/mL in EtOH with ultrasonic
form: solid
pka: 8.67±0.23(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 10443
Product name: SB939
Purity: ≥98%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 10443
Product name: SB939
Purity: ≥98%
Packaging: 5mg
Price: $140
Updated: 2024/03/01

Cayman Chemical

Product number: 10443
Product name: SB939
Purity: ≥98%
Packaging: 10mg
Price: $257
Updated: 2024/03/01

Cayman Chemical

Product number: 10443
Product name: SB939
Purity: ≥98%
Packaging: 25mg
Price: $586
Updated: 2024/03/01

Usbiological

Product number: 019878
Product name: Pracinostat
Packaging: 10mg
Price: $460
Updated: 2021/12/16

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Pracinostat Chemical Properties,Usage,Production

Uses

Pracinostat is a potent and orally active histone deacetylase (HDAC) inhibitor with high tumor exposure and efficacy in mouse models of colorectal cancer. The selectivity of Pracinostat for tumor tissues makes it a promising therapeutic candidate for use in patients with advanced solid malignancies. Potent Histone deacetylase inhibitor.

Definition

ChEBI: Pracinostat is a hydroxamic acid that is N-hydroxyacrylamide which is substituted at position 3 by a 2-butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl group (the E isomer). An orally available pan-histone deacetylase inhibitor with demonstrated activity in the treatment of advanced solid tumours. It has a role as an EC 3.5.1.98 (histone deacetylase) inhibitor, an antineoplastic agent, an apoptosis inducer and an antimalarial. It is an olefinic compound, a hydroxamic acid, a benzimidazole and a tertiary amino compound.

Biological Activity

pracinostat, also known as sb939, is a potent and orally available inhibitor of histone deacetylase (hdac) with a relatively stronger selectivity (more than 1000-fold) for class i, class ii and class iv hdacs rather than class iii hdacs. pracinostat potently suppresses proliferation in a wide range of cancer cell lines, including colon cancer, ovarian cancer, prostate carcinomas, acute myeloid leukaemia (aml) and b cell lymphoma. recent study results have shown that sb939 induces the accumulation of acetylated histone h3 (ach3) and acetylated α-tubulin and increases the expression of the cyclin dependent kinase inhibitor p21 in cancer cells.razak ar, hotte sj, siu ll, chen ex, hirte hw, powers j, walsh w, stayner la, laughlin a, novotny-diermayr v, zhu j, eisenhauer ea. phase i clinical, pharmacokinetic and pharmacodynamic study of sb939, an oral histone deacetylase (hdac) inhibitor, in patients with advanced solid tumours. br j cancer. 2011;104(5):756-762.

target

HDAC1

Pracinostat Preparation Products And Raw materials

Raw materials

Preparation Products

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Pracinostat Suppliers

Canada 1 China 120 India 2 United Kingdom 1 United States 18 Global 142

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2784
Advantage: 58

ApexBio Technology LLC

Tel: +1-832-696-8203
Fax: +1-832-641-3177
Email: info@apexbt.com
Country: United States
ProdList: 477
Advantage: 60

Target molecule Corp.

Tel: 857-239-0968
Fax: 857-239-8801
Email: service1@targetmol.com
Country: United States
ProdList: 2559
Advantage: 60

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4662
Advantage: 60

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 19892
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6393
Advantage: 58

Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
Country: United States
ProdList: 2738
Advantage: 58

BOC Sciences

Tel: +1-631-485-4226
Fax: 1-631-614-7828
Email: inquiry@bocsci.com
Country: United States
ProdList: 19553
Advantage: 58

Aladdin Scientific

Tel: +1-833-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57511
Advantage: 58

929016-96-6, PracinostatRelated Search:

HEXABUTYLDITIN 4-Methyl-2-pentanone SB-705498 SB 203580 SB 225002 SB242235 2-(5-Benzo[1,3]dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrate hydrochloride 3--Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide WP1066 WP1130 (2E)-3-(4'-Hydroxy-3'-tricyclo[3.3.1.13,7]dec-1-yl[1,1'-biphenyl]-4-yl)-2-propenoic acid BAY 11-7085 ML264 ACY-1215 AR-42 Panobinostat JNJ-26481585 Mocetinostat (MGCD0103)

Pracinostat (SB939)

SB939

(2E)-3-[2-Butyl-1-[2-(diethylaMino)ethyl]-1H-benziMidazol-5-yl]-N-hydroxy-2-propenaMide

(2E)-3-[2-Butyl-1-[2-(diethylaMino)ethyl]-1H-benziMidazol-5-yl]-N-hydroxyacrylaMide

(E)-3-[2-Butyl-1-(2-diethylaMinoethyl)-1H-benziMidazol-5-yl]-N-hydroxy-2-propenaMide

KaeMpferol 3-O-β-D-(6-E-p-CouMaroylglucoside)

Pracinostat

2-Propenamide, 3-[2-butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl]-N-hydroxy-, (2E)-

Pracinostat, >=98%

(E)-3-[2-butyl-1-[2-(diethylamino)ethyl]benzimidazol-5-yl]-N-hydroxyprop-2-enamide

(E)-3-(2-BUTYL-1-(2-(DIETHYLAMINO)ETHYL)-1H-BENZO[D]IMIDAZOL-5-YL)-N-HYDROXYACRYLAMIDE

(2E)-3-[2-Butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl]-N-hydroxyacrylamide Pracinostat (SB939)

SB 939 Pracinostat

Pracinostat Hydrochloride

PRACINOSTAT (SB939);SB939; SB-939

CS-60

SB939; SB-939; SB 939

PRACINOSTAT (SB939), >98%

SB939, >98%

Pracinostat USP/EP/BP

929016-96-6

Amines

Aromatics

Heterocycles

Inhibitors

Intermediates & Fine Chemicals

Pharmaceuticals

Inhibitor